Webinar: Mechanisms of Catalytic Sugar Conversion: Bridging the Gap between Catalysis Disciplines
Speaker: Dr. Evgeny Pidko, University of Technology Eindhoven
Date: 19th November 2014
Abstract: One of the main challenges in the valorization of carbohydrate fraction of biomass is its efficient and selective conversion to platform chemicals with a wide range of downstream applications. While different homogeneous and heterogeneous catalysts can be used to selectively convert fructose , the activation of the more abundant glucose sugar is much more difficult. The direct conversion of glucose represents a challenge not only for the chemocatalysis but also for biological systems. The vast majority of glucose conversion paths starts from aldose-ketose isomerization step that transforms glucose to its more reactive isomer – fructose. In industry, fructose is produced via the enzymatic isomerization of glucose syrup. Despite the high activity, the potential of the biocatalyst integration in a multistep process to produce biomass-derived platform chemicals is limited. Unlike enzymes, chemocatalysts efficiently operate within large ranges of temperatures, pressures and pH. From this perspective, inorganic Lewis acids are particularly attractive as catalysts for the selective glucose activation. Both homogeneous and heterogeneous Lewis acids can promote the glucose to fructose isomerization. In particular, glucose can be isomerized by homogeneous systems based on Cr (II) and (III) chlorides in ionic liquids [2,3] and by heterogeneous Sn-BEA zeolite catalyst able to operate in aqueous medium . There is a fundamental question regarding the systems outlined above: what do they have in common besides their isomerization activity and Lewis acidity. In this lecture I will discuss the results of our recent computational and experimental studies on the mechanism of glucose isomerization by these very different systems[3,5]. I will demonstrate that the enzymatic and chemocatalytic systems utilize similar tools to selectively activate carbohy-drates. They all make use of the dynamic and cooperative action of their active sites towards selective glucose transformation. Despite obvious differences between these catalytic systems, the structures and properties of the key intermediates and transition states are strikingly similar. The fundamental insights obtained in these studies pave the way towards the rational design of new carbohydrate conversion catalysts.
On the 19th November 2014 at 9am (UK time), Novacam held a webinar to present the topic of “Mechanisms of Catalytic Sugar Conversion: Bridging the Gap between Catalysis Disciplines” to an International audience.
If you were not able to join this Novacam Webinar, or would like to have a re-cap of the presentation from Dr. Evgeny Pidko, then please follow the links below.
Other webinars in the series: